Education:

• Washington University in St. Louis, M.S. in Biomedical Engineering, 2006
• Washington University in St. Louis, Ph.D. in Biomedical Engineering, 2008
• Harvard University, School of Engineering and Applied Science, Postdoc, 2008
• Massachusetts General Hospital, Cardiovascular Research Center, Postdoc, 2009

Department: Pharmacology
Research Interests:

Cardiovascular pharmacology

Research Summary:

We think that seeing is believing; thus the major approach used in our lab is to combine multiple imaging modalities across multiple spatial scales to determine factors contributing to cardiac arrhythmias. In vivo molecular and structural imaging combined with ex vivo high-speed, high-resolution functional optical imaging of transmembrane potential and intracellular calcium in isolated hearts is used to systematically characterize individual factors contributing to arrhythmia. Using this integrative approach to better understand the mechanisms of arrhythmia genesis and maintenance in different disease states, we hope to develop novel anti-arrhythmic therapies that target the underlying causes of cardiac arrhythmias.

Highlighted Techniques:

High-speed fluorescent imaging, Cardiovascular molecular imaging

Lab Members:

Lianguo Wang, M.D., Assistant Project Scientist, Nicole De Jesus, Graduate Student, BME Graduate Group

Lab Rotation Availability: Yes
Funding Sources: National Institutes of Health, American Heart Association
PubMed listing