Education:

• Cornell University; Ithaca, NY, Biology, B.S., 1989
• University of Utah; Salt Lake City, UT, 1996, Biochemistry, Ph.D., 1996
• Scripps Research Institute; La Jolla, CA, 2000, Molecular Biology, PD, 2000

Department: Biochemistry and Molecular Medicine
Research Interests:

Zinc finger proteins, Diagnostics, Gene therapy

Research Summary:

Almost every disease has a genetic component. Often this information is used only to determine how condemned a person is to develop disease. We would like to use the genetic information to fix the disease. A guiding principle for our work has been to study how nature does what it does, then attempt to use that knowledge to make useful tools to improve public health, either through increased knowledge or therapeutic intervention. Specific research foci in the Segal Lab revolve around engineering custom zinc finger DNA-binding proteins for specific applications. We also continue to make methodological improvements, many of which have been widely adapted in the field.

Courses/Teaching:

• PHA 400C. Principles of Pharmacology
• PHA 225. Gene Therapy
• PHA 250. Functional Genomics: From bench to bedside
• MCB 211: Physical Biochemistry - DNA section
• MCB 221A. Physical Biochemistry
• BCM 410A. Molecular and Cell Biology
• FRS 001. Freshman Seminar: Gene therapy: How genes control you and how you can control them

Funding Sources: National Institutes of Health, Angelman Syndrome Foundation, UC Davis-Lawrence Livermore Laboratory
PubMed listing