Position Title
Professor
- Internal Medicine - Pulmonary
Education:
- Ph.D., Russian Academy of Sciences, Moscow, Russia 2000
- M.S., Moscow Lomonosov State University, Moscow, Russia 1993
Department: Internal Medicine | Division: Pulmonary, Critical Care and Sleep Medicine
Director: Pulmonary Vascular Disease Program - UC Davis Lung Center
Research Interests:
Our research interests have focused on the molecular and cellular mechanisms of pulmonary vascular disease, specifically pulmonary arterial hypertension (PAH). Our goals are:
-to dissect new signaling hubs driving hyper-proliferation of resident pulmonary vascular cells, pulmonary vascular remodeling and PAH;
-to identify and pre-clinically validate novel molecular target pathways for therapeutic intervention;
-to develop in vitro human-based models for molecular and pre-clinical studies.
Current Projects:
(1) mTOR signaling network and growth suppressor TSC2 pulmonary vascular cell remodeling and right ventricular dysfunction in pulmonary arterial hypertension
(2) the role of HIPPO signaling cassette in pulmonary vascular cell hyper-proliferation, development and progression of pulmonary hypertension
(3) GATA6 transcriptional factor as a regulator of pulmonary vascular cell-cell communications, BMP signaling and inflammation in pulmonary hypertension
(4) lipid metabolism as a regulator of pulmonary vascular remodeling and pulmonary hypertension
Lab Rotation Availability: Upon Inquiry