Education:

• University of Maryland, Toxicology, Ph.D., 1983
• University of Maryland, Toxicology, M.S., 1981
• Cornell University, Biology, B.S., 1977

Department: Molecular Biosciences
Research Interests:

Neuropharmacology and Toxicology, Cardiovascular pharmacology and toxicology, Gene by environment interactions, Neurodevelopmental disorders, Ryanodine receptors and Ca2+ signaling

Research Summary:

Research interests are in the broad area of molecular and cellular mechanisms regulating local Ca2+ signaling in muscle, neurons, and immune cells. Organization and function of macromolecular signaling complexes known as ryanodine receptors and how environmental chemicals including PCB's, PBDE's, and triclosan, influence developmental toxicity through these complexes. Gene-environment interactions influencing susceptability in autism and related disorders are studied in mice possessing missense mutations known to contribute susceptibility to human disease.

Courses/Teaching:

• PTX 202. Principles of Pharmacodynamics and Toxicodynamics
• VMD 414A. Principles of Pharmacology
• VMD 403. Pharmacodynamics Physiological Chemistry

Lab Members:

Wei Feng, Gennady Cherednychenko, Diptiman Bose, Zhengyu Cao, Susan Hulsizer, Kim Truong, Ray Zhang, Yassaman Niknam, Erika Holland, Stevie Maxwell, Rebecca Morrison (CCEH Administrator)

Funding Sources: UC Davis Superfund
PubMed listing