- Environmental Toxicology
- University of Cologne & University of Osnabrück, Germany, Protein Biochemistry, Ph.D., 2008
- University of Cologne, Germany, Biological Sciences, M.S., 2005
Our main research focuses on understanding the molecular mechanisms underlying chemical uptake and distribution in humans and other organisms. The Nicklisch Lab is interested in determining levels of drugs and environmental chemicals in different types of foods and to biochemically characterize their interactions with protective drug transporters, including P-glycoprotein, MRP1 and BCRP. Current efforts in the lab focus on investigating possible drug-pollutant and pollutant-pollutant interactions with P-glycoprotein other drug transporters on a molecular and organismal level.
The Nicklisch Lab has demonstrated expertise in a broad range of traditional lab techniques to determine structure and conformation of proteins, including NMR and EPR spectroscopy and Circular Dichroism spectrometry. In addition, we have a proven track record of developing and optimizing new biochemical assays and analytical tools to determine enzyme and transporter function and kinetics. Our lab has pioneered the field of toxicokinetic interactions of environmental chemicals with drug transporters as novel targets for understanding the molecular mechanisms underlying chemical bioaccumulation.
Lab Rotation Availability: Yes